Zopiclone 7.5mg Tablets (ZOP)

£20.00£80.00

Zopiclone 7.5mg Tablets

Category: CNS depressant

Active ingredient: Zopiclone

Inactive ingredients: Calcium hydrogen phosphate, lactose, starch wheat, sodium starch glycollate, magnesium stearate, hypromellose, titanium dioxide, and macrogol.

10 tablets

Therapeutic indications

Zopiclone is recommended for the short-term treatment of insomnia. Generally, the treatment period shouldn’t be longer than 2-4 weeks. Your body can get used to it very quickly, and after this time it is unlikely to have the same effect. Also, your body can become dependent on it. That is why Zopiclone is recommended for the short-term treatment of transient, situational and chronic insomnia characterized by difficulty in falling asleep, frequent nocturnal awakenings and early morning awakenings.

Contraindications

We recommend you to first consult your doctor in the following cases:

  • If you are allergic to Zopiclone or any other ingredients present in the tablets;
  • If you have depression or a personality disorder;
  • If you are pregnant or planning to become pregnant;
  • If you are a nursing mother;
  • If you have a breathing disorder, such as asthma, sleep apnoea, or emphysema;
  • If you have a history of alcohol or substance abuse;
  • If you have impaired liver or kidney function due to a medical condition;
  • If you have Myasthenia Gravis (a disease characterized by muscle weakness);
  • If you are an elderly individual.

Side effects

Zopiclone can have side effects, some of which are more common and others are less common. Side effects of Zopiclone which may occur are:

  • Unsteadiness or clumsiness;
  • Confusion;
  • Daytime restlessness or anxiety;
  • Difficulty with coordination;
  • Mental or mood changes;
  • Dry mouth;
  • Changes in taste;
  • The feeling of tiredness;

Less common:

  • Aggressiveness;
  • Behaviour changes;
  • Laboured or difficult breathing;
  • Severe drowsiness;
  • Shortness of breath;
  • Skin rash;
  • Tightness in the chest;
  • Wheezing;
  • Anxiety;
  • Headaches;
  • Nausea;
  • Changes in libido.

It is always recommended to consult a doctor if you encounter any of the side effects.

Zopiclone is also known under the trade names: Zimovane, Imovane, Ran-Zopiclone, Rhovane Zimovane, Zileze, Zimoclone, Zopitan, Zorclone.

SKU: Zopiclone7.5mgTablets Category:

Description

Pharmacology

Zopiclone is used to treat insomnia. It helps you fall asleep more quickly, improves the quality of your sleep, stops waking up during the night or too early in the morning. Also helps in case of severe problems of sleep due to mood or mental health problems.

Zopiclone 7.5 mg belongs to the group of medicines called Central Nervous System (CNS) depressants. It is used for sleep induction because of its calming effect on the brain. Zopiclone is ‘’ non-benzodiazepine’’ agonist of benzodiazepine receptors. Also have sedative, anxiolytic, muscle-relaxing center, anticonvulsant and amnesic properties. Zopiclone enhances GABA-ergic processes in the brain, interacting with the benzodiazepine receptors, as a result of the increased sensitivity of GABA-receptors to the neurotransmitter.

Being a derivative of benzodiazepine, Zopiclone shares an almost identical pharmacological profile to them. However, Zopiclone interacts with other parts of the benzodiazepine receptor than benzodiazepines. It acts as a full agonist, which in turn positively modulates benzodiazepine-sensitive GABAa receptors and enhances GABA binding at the GABAa receptors to produce Zopiclone’s subjective effects. Since GABA functions as the brain’s predominant inhibitory neurotransmitter, such activation of receptors results in the sedative and anxiolytic effects of Zopiclone.

Pharmacokinetics

Zopiclone is rapidly absorbed, with a bioavailability of approximately 80%. The peak plasma concentration of 60 ng/mL is achieved within 90minutes. The plasma protein binding of zopiclone has been reported to be between 45 and 80%. Zopiclone is partly metabolized in the liver to form an inactive N-demethylated derivative and an active N-oxide metabolite. Approximately 50% of the administered dose is decarboxylated and excreted via the lungs. Less than 7% of the drug is also excreted in unchanged form.

Indications

Zopiclone should be used only for short periods of time, such as 1 or 2 days, and generally for no longer than 2-4 weeks. Your body can get used to it very quickly, and after this time it is unlikely to have the same effect. Your body can also become dependent on it. That is why Zopiclone is recommended for the short-term treatment of transient, situational and chronic insomnia characterized by difficulty in falling asleep, frequent nocturnal awakenings and early morning awakenings.

Dosage and administration

The recommended dose of Zopiclone is 7.5 mg orally at night, it takes around 1 hour to work. In cases of severe insomnia, the dose can be increased up to 15 mg. A lower dose of 3.5mg may be recommended for elderly patients or if a patient has kidney or liver problems. Taking a lower dose in these cases reduces the risk of excessive sleepiness and other side effects.

Side effects

Side effects of Zopiclone which may occur are a bitter or metallic taste in your mouth, a dry mouth, daytime sleepiness, disruption of REM sleep, double vision, drowsiness, memory impairments, visuospatial impairments, dizziness, headaches, and fatigue. Unexpected mood changes have been noted, which if experienced should lead to the drug being withdrawn from the patient. Also, palpitations may occur in the daytime following withdrawal from the drug after prolonged periods of use (especially when taken for more than two weeks).

Serious side effects are rare, but also are possible. Immediately contact your doctor if you:

  • lose your memory;
  • see or hear things that aren’t real;
  • fall over, especially if you’re elderly;
  • think things that aren’t true – these are called delusions;
  • feel low or sad – this could be a sign of depression.

If you have a bitter or metallic taste in your mouth or a dry mouth – try sipping water. Impairment of driving skills with a resultant increased risk of road traffic accidents is probably the most important side effect. If you feeling sleepy or tired – don’t drive. This side effect is not unique to Zopiclone but also occurs with other hypnotic drugs.

Medical attention should be sought immediately in case signs of a serious allergic reaction to Zopiclone.

Pregnancy

If you are currently planning to become pregnant, discuss this issue with your obstetrician or other doctors. Zopiclone is contraindicated during pregnancy (especially in I and III trimesters, it may harm the developing baby) and lactation (breastfeeding). It can cause side effects in newborn babies. If a woman uses Zopiclone in III trimesters of pregnancy there are possible violations of the nervous system in the newborn, the emergence of withdrawal syndrome. The use of Zopiclone can increase your risk of having a baby born early (before 37 weeks). If the woman is prescribed by a doctor took Zopiclone immediately prior to labor and delivery, it needs constant medical surveillance for the newborn. At the time of treatment, it should be stopped breastfeeding (Zopiclone penetrates into breast milk).

Special instructions and precautions

Caution should be exercised in patients with a history of psychiatric disorders, drug abuse, kidney or liver disease, during pregnancy and breastfeeding.

  • The use of Zopiclone may cause dizziness or drowsiness.
  • Don’t drink alcohol while you’re on Zopiclone.
  • Avoid long-term use of Zopiclone, otherwise, you may get addicted to this drug.
  • Do not drive a car or operate machinery while taking Zopiclone.

Zopiclone drug interactions

Zopiclone may interact with some other medications and increase the chances of having side effects. Be aware that if you are taking these drugs together, such interaction can be harmful. Examples of the drugs which may increase the sedating effects of Zopiclone:

  • medicines to treat depression;
  • medicines for epilepsy;
  • medicines to treat schizophrenia and bipolar disorder;
  • strong painkillers (such as codeine, methadone, morphine, pethidine, oxycodone, tramadol);
  • medicines used in surgery (anaesthetics);
  • medicines to calm or reduce anxiety, or for sleep problems;
  • some medicines used to treat fungal infections (such as ketoconazole and itraconazole);
  • Ritonavir (a medicine used to treat HIV infections);
  • medicines for hay fever, rashes, or other allergies that can make you sleepy (sedative antihistamines, such as chlorphenamine or promethazine);
  • erythromycin or clarithromycin (antibiotics used to treat infections).

Overdose

Symptoms of Zopiclone overdose may include one or more of the following symptoms: excessive drowsiness, slow, shallow breathing, pale skin, sudden onset of sweating, blurred vision and loss of consciousness. In case of emergency/overdose immediately contact your local poison control center or emergency room.  Respiration, pulse and blood pressure should be monitored and supported by general measures when necessary. Immediate gastric lavage should be performed.

Additional information

Zopiclone 7.5mg Tablets

10, 50, 100